DEVELOPMENT OF BIOSIMILARS IN BRAZIL

Development of Biosimilars in Brazil

This article presents a brief overview of the biosimilar industry in Brazil and in Accent Table Package the world.Biosimilars are drugs originating from therapeutic or biological proteins, whose patents are expired or are going to expire.Similarly to the generic pharmaceutical industry, the expiration of patents for biologics allows the emergence o

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Role of critical elements in botulinum neurotoxin complex in toxin routing across intestinal and bronchial barriers.

The highly potent botulinum neurotoxin serotype A (BoNT/A) inhibits neurotransmitter release at neuromuscular junctions resulting in flaccid muscle paralysis, respiratory arrest and death.In order to reach their neuronal cell targets, BoNT/A must cross epithelial cell barriers lining the intestines and airways.The toxin is produced as a large prote

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